Structure–property relationships in halogenated aromatic amides and imides

Aromatic benzotriazole amides--synthesis and biological evaluation.

Four derivatives of benzotriazole-5-carboxylic acid were synthesized as potential UV-light dependent DNA cleaving agent. The effect of these compounds on phiX174 RF1 phage DNA and pBR322 plasmid DNA was investigated with and without UV exposure. It has been found that the two compounds exert the influence on topological forms of DNA.

Health effects of halogenated aromatic hydrocarbons.

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Analysis of Halogenated Polycyclic Aromatic Hydrocarbons in the Air

DNA-catalyzed hydrolysis of esters and aromatic amides

Relief of procaspase inhibition enhances the potency of cancer chemotherapeutics Botham RC, Fan TM, Hergenrother PJ Manipulation of the apoptotic cascade is an effective and commonly employed strategy for the eradication of cancer cells. This work utilizes the small molecule PAC-1 to target the labile zinc pool, a physiological inhibitor of apoptosis. Labile zinc inhibits the conversion of proc...

DNA-catalyzed hydrolysis of esters and aromatic amides.

We previously reported that DNA catalysts (deoxyribozymes) can hydrolyze DNA phosphodiester linkages, but DNA-catalyzed amide bond hydrolysis has been elusive. Here we used in vitro selection to identify DNA catalysts that hydrolyze ester linkages as well as DNA catalysts that hydrolyze aromatic amides, for which the leaving group is an aniline moiety. The aromatic amide-hydrolyzing deoxyribozy...